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Stem cell niches may reactivate in cleared tissue Months 1-6+: Gradual tissue remodeling and functional recovery in organs where senescent cell burden was reduced This cascade explains why FOXO4-DRI doesn't produce immediate, obvious effects

However, a subsequent retrospective study of 100 men exposed no statistically significant differences in efficacy for pain relief, penile curvature, or plaque size between colchicine and colchicine combined with vitamin E (17)

doi: 10.1016/j.jff.2015.09.004 191