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subsequent preclinical studies have thus screened agonists with primates with Trp33 ECD or receptor mutants with substitution of Ser33 ECD by Trp33 ECD
For patients with obvious stomach issues or indications of slow metabolism, or those on higher doses, many surgeons request that they discontinue the medication early
But its GI side effect profile is also the most aggressive, with nausea rates reaching 40% to 50% and vomiting rates significantly higher than cagrilintide monotherapy
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