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The researchers assessed the hepatic capacity for synthesizing urea-N (CUNS), which is a potential indicator of nitrogen metabolism in the liver
Gastrointestinal symptoms including nausea, vomiting, diarrhea, constipation, and abdominal discomfortare the most frequently reported adverse effects, occurring in 20-30% of patients (varying by dose and population), particularly during dose escalation
Digiesi V, Palchetti R, Cantini F
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