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Principalmente, estos medicamentos estimulan la secrecin de insulina de manera dependiente de la glucosa, lo que significa que solo actan cuando los niveles de azcar en sangre estn elevados, reduciendo as el riesgo de hipoglucemia (aunque este riesgo aumenta cuando se combinan con sulfonilureas o insulina)
Effective for Long-Term Weight Loss A trial published in Nature Medicine found that, on average, Semaglutide led to a 10.2% weight reduction after 208 weeks
GLP-1 receptor agonists and pancreatitis: a pharmacovigilance study
However, research on liraglutide, including a 31-study meta-analysis of over 8,000 patients, has shown that injection of GLP-1 agonists stimulates the same effect on the vagus nerve whether stomach tissue is distended or not
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