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GHK-Cu's published research arc reaches back to its 1973 isolation from human plasma by Loren Pickart, with subsequent genomic profiling identifying expression changes across roughly 4,000 human genes
Glutathione is central to liver detoxification
Cell Metabolism , 27(6), 1212-1221
This uncertainty is the core reason systemic use cannot be considered well characterized
GHK-Cu's advantage is the combination of broad gene expression modulation with established topical delivery and decades of cosmetic safety data
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