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A proportion of those with an imprinting defect have a microdeletion in the Imprinting Center
This is called pulmonary aspiration
Our study does not suggest that cutaneous adverse events are common enough to limit their use, but rather that dermatologic reactions are part of the broader safety profile and may be underrecognized
However, older adults tend to have lower baseline body water, which affects distribution volume
Rapid titration or initiating at higher doses increases the chance of early nausea because compensatory physiological adaptation is outpaced
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