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Safety must be prioritized over efficacy claims
doi: 10.1001/jama.2024.3073 Summary Keywords obesity, obesity pharmacotherapy, precision medicine, personalized treatment, combination therapy, weight management, weight loss Citation Steenackers N, Toumassian J, Deleus E, Mertens A, Lannoo M, Pazmino S, van Laar ADE, Van der Schueren B and Vangoitsenhoven R (2025) Pharmacotherapy for obesity: are we ready to select, tailor and combine pharmacotherapy to achieve more ambitious goals
This warning originates from rodent studies where semaglutide caused dose-dependent thyroid C-cell tumors in rats and mice