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Gradual dose titration, as recommended in the prescribing information, helps minimise adverse effects regardless of administration time
However, the identification of other canonical pathways represented among the genes whose expression is altered by r-hGH emphasizes the complexity of the potential mediators of GH action in addition to IGF-I (Table 3)
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Generally, low cardiovascular risk is typically defined as the absence of cardiovascular disease and a Flemingham 10-year risk of cardiovascular events less than 20% (39, 40)
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