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These dose-dependent symptoms are usually mild, fading in weeks, but demand caution in severe GI conditions like IBD or gastroparesis

Severe dehydration from vomiting and diarrhea can escalate quickly, particularly in older adults

You might notice hunger showing up sooner, thinking about food more often, or meals not keeping you full as long

In addition, T1D-tolLNP-treated mice had a trend towards increased frequencies of CD25+FoxP3+ T cells (Tregs) and PD1+ Tregs frequencies compared to buffer-injected control mice at 16 weeks of age

Reaching your final maintenance dose of semaglutide typically takes around 17 weeks