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Evaluation of: Glycerol production (a marker of lipolysis) 2-deoxyglucose uptake (a marker of insulin signaling) DNA synthesis (a marker of proliferation) What they found: AOD-9604 stimulated lipolysis dose-dependently from 10 M, with a plateau at 10 M Full hGH stimulated lipolysis to a similar maximum, but with different kinetics AOD-9604 did not affect glucose uptake or DNA synthesis at all, whereas hGH inhibited both (the classic lipotoxic GH effect) Fragments with different sequence (from the N-terminal part of hGH) had no lipolytic effect Why it matters: This was the first publication of AOD-9604

Other storage sites include the kidney, heart, spleen, and brain

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Electrolyte balance in the human body is necessary for cell signaling, nerve impulse conduction, muscle contraction, heart rhythm, kidney function, and fluid balance

Compared with the control group, the treated mice showed a 35% decrease in white adipose tissue mass and markedly reduced adipocyte size