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It works by activating GLP-1 receptors, which help control blood sugar and reduce hunger
By attaching itself to its receptors and activating adenylate cyclase (AC), which raises cAMP levels in the myocardium, glucagon also increases cardiac output
GLP-1 medications are contraindicated during pregnancy
GLP-1 is released from intestinal L-cells in a biphasic pattern following meal ingestion: an initial early peak within 1015 minutes, driven primarily by neural and endocrine signals from the upper gastrointestinal tract, is followed by a sustained second peak at 3060 minutes driven by direct nutrient contact with L-cells in the distal ileum and colon
Others lose muscle along with fat, which makes long-term maintenance harder because muscle tissue supports metabolic health, movement, insulin sensitivity, and day-to-day resilience
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