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Research Evidence Comparison# Retatrutide Research# Phase 1 : First-in-human study established safety and pharmacokinetics Phase 2 (n=338) : Published in NEJM (2023), demonstrated dose-dependent weight loss up to 24.2% at 48 weeks with 12 mg dose

Patients with type 2 diabetes who are about to begin, or who have recently begun, taking a GLP-1 drug should have a baseline dilated eye examination to determine their level of DR

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It warns that a weakened injection may not deliver the expected appetite suppression or metabolic benefit, so patients can wrongly conclude the medication itself is not working

L-carnitine is among the more controversial supplements