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They postulate the pain felt by patients is out of proportion to the damage seen, the pain is not just because cartilage over the bone gets worn down. They state the thin rim of the cartilage becomes inflamed and sends pain signals to the body
& Valverde, I
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The weight loss achieved varies by specific medication and dose: semaglutide 2.4 mg (Wegovy) produces approximately 15% weight loss, tirzepatide (Zepbound) up to 15-22%, and liraglutide 3 mg (Saxenda) about 5-8%
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