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During this window, you'll discover your ideal dose, tolerate side effects, and confirm that semaglutide fits your lifestyle
Therefore, it can worsen high blood pressure, cause heart racing, and cause anxiety
If metformin doesnt work well enough on its own, a GLP-1 RA is often added to the treatment plan
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However, your doctor must monitor your readings closely during the first 48 weeks because semaglutide can lower blood pressure, potentially requiring dose adjustments to your hypertension medications
![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
