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Semaglutide and tirzepatide products have different indications, dosing schedules, contraindications, warnings, and side-effect profiles

The latter one which included 4 trials (43,456 patients) suggested that GLP-1 RAs reduced MACE by 13% (HR 0.87, 95% CI 0.820.93), an effect which was consistent in both subgroups (HR 0.91, 95% CI 0.850.97 and HR 0.80, 95% CI 0.720.90 with and without metformin, respectively)

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Ruggiero R, Mascolo A, Spezzaferri A, Carpentieri C, Torella D, Sportiello L, et al

In STEP 1 (semaglutide 2.4 mg, 1,961 participants), most weight loss occurred by weeks 30 to 40, with the curve flattening after that