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These are consistent with the mechanism of action slowing gastric emptying affects digestion, and central appetite suppression can cause nausea, particularly during the early stages of treatment and dose escalation

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Tirzepatide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and should not be used during pregnancy due to potential fetal harm

Telomerase modulation may influence the timing of senescence onset in dividing cells