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Patients should use non-oral contraceptive methods or add a barrier method for 4 weeks after tirzepatide initiation and after each dose increase

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This evidence supports proactive medication adjustment rather than watchful waiting

Acylcarnitine stabilizes the expression of lncBCL2L11 through the m6A modification and participates in the positive feedback loop of tumor cell invasiveness, which provides a powerful driving force for the malignant progression and metastasis of gallbladder cancer [44]