The 2-8C range is the pharmaceutical standard for biologics storage because it minimizes both freeze damage and thermal degradation
112 However, in recent years, the FDA has introduced the patient-focused drug development initiative, where patient-reported outcomes such as improvements in quality of life and healthy life years in MASH patients following treatment can serve as trial endpoints, potentially influencing final approval based on these data
Confirmation of a direct role for GSTP1 in chemotherapy response is important, not only in the prediction of response to platinum-based chemotherapy, but as a candidate response biomarker for new generation chemotherapy drugs, designed to exploit increased GSTP1 expression in tumours relative to surrounding normal tissues
Van Den Boorn JG, Konijnenberg D, Dellemijn TA, Van Der Veen JW, Bos JD, Melief CJ, Vyth-Dreese FA, Luiten RM
Rest with your head elevated, ideally on two firm pillows, for the first 24 hours