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The phase 2 trial published in The New England Journal of Medicine in 2023 enrolled adults with obesity without type 2 diabetes and demonstrated dose-dependent weight loss of up to 24.2% of body weight at the highest dose over 48 weeks results that attracted considerable scientific and media attention
This is well-established in the bariatric surgery literature, and the same principles apply to medication-assisted weight loss
What to do if retatrutide does not seem to be working Some people reach week four, six, or even eight without seeing the results they expected
It makes clear that abuses are crimes and that punishment may be warranted
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