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Severe caloric restriction depletes these reserves, whilst hormonal changes from rapid weight loss compound the effect by altering thyroid function and increasing cortisol levels, further disrupting normal follicular activity

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doi: 10.3390/ijms22147475 78 van OostveenWMde LangeECM

[3] [4] It targets three key hormonal receptors simultaneously: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor