Secondary Outcome: Secondary Outcomes: Changes in waist circumference, body fat, body lean mass, and metabolic risk factors including levels of plasma glucose, insulin sensitivity, serum lipids, and blood pressure Statistical Analysis Full details previously published 2 and can also be found in the STEP group statistical analysis plan at NEJM.org Statistical analysis approach sought strong control for type I error All endpoints addressing intervention efficacy were analyzed using intention-to-treat approach All endpoints addressing intervention safety were analyzed using per-protocol approach Efficacy endpoints analyzed using 2 estimands Treatment Policy Estimand: intention to treat analysis
Most pens click in 0.25 mg increments, so reaching 0.5 mg requires two clicks from the starting position
For the first time in years, her menstrual cycles became regular, and her A1C levels dropped from 10.2% to 6.5% within just three months - a clear sign of improved insulin resistance
Vitamin C improves collagen production by turning on fibroblasts which improve the appearance of fine lines
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