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Phase 2: weeks 5 through 12 (building momentum) By week five, most people have adapted to the initial dose and gastrointestinal side effects have diminished significantly

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These data are in agreement with previous reports that GIP antagonism or genetic deletion of GIPR ameliorates DIO (50)

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Tirzepatide is a dual-agonist, targeting both GIP and GLP-1 receptors, which may provide enhanced metabolic effects

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