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The system x c , consisting of the proteins SLC7A11 and SLC3A2, facilitates the exchange of transfer between cystine and glutamine, thereby playing a crucial role in cystine uptake and promoting GSH synthesis
At the same time, it has a similar function to GPX7, which can increase the PDI activity of ER redox protein 1 (ERO1), promote the oxidative folding of endoplasmic reticulum proteins, and reduce oxidative stress (Raykhel et al., 2007)
The unexpected activity can be explained by the formation of variable amounts of disulfide-bridged PfGrx C32S/C88S homodimers and potential Diamide-modified monomers, summarized as PfGrx C32S/C88S (SX), as revealed by non-reducing SDS-PAGE (Fig
This activation triggers protein kinase C (PKC) and mobilizes intracellular calcium reserves through the inositol trisphosphate/diacylglycerol pathway
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