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The company has been actively strengthening its oncology pipeline through acquisitions, including the up to $1.15 billion purchase of US biotech IDRx, which brings the late-stage gastrointestinal cancer candidate IDRX-42, a KIT-selective tyrosine kinase inhibitor for gastrointestinal stromal tumors
To explore the role of GPx4 during embryo development targeted constitutive GPx4 knockout mice were created (Imai et al., 2003
This dual mechanism provides: GLP-1 receptor activation: Enhanced glucose-stimulated insulin secretion, slowed gastric emptying, and increased satiety signaling GIP receptor activation: Additional insulin secretion support and potential effects on lipid metabolism and fat deposition Tirzepatide gained regulatory approval in 2023 and has been extensively studied in Phase 3 clinical trials with larger patient populations and longer durations
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The trade-off is that the gut side effects tend to ease at the same time
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