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Under hypoxic conditions, the nonadaptive cancer cells undergo apoptosis via HIF-1- and P53-dependent mechanisms
Archived from the original on March 9, 2023
The TRIUMPH-1 trial showed 24% body weight reduction at 12mg over 48 weeks a number that put the entire GLP-1 space on notice
Senescent cells are cells that have permanently halted their cell cycle ('replicative arrest') but resist apoptosissometimes called 'zombie cells.' They accumulate with age in multiple tissues and secrete a pro-inflammatory cocktail called the Senescence-Associated Secretory Phenotype (SASP), containing IL-6, IL-8, MMP-3, MMP-9, TNF-, and other factors that damage surrounding healthy tissue
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