glp 1 dual agonist GIP/GLP-1 receptor agonists: New advances for treating type-2 diabetes Effects, working principles and target

& van den Brink, M

In individuals with normal B12 metabolism and no ongoing deficiency, the body's stores can theoretically last several years

Metabolic studies Animals were given either 6 g/kg glucose or distilled water (2 mL/100 g body weight, n = 10 for all groups) by gavage every 6 h (at 06:20, 12:20, 18:20, and 24:20 h) for 38 days, defined as the long-term oscillating glucose (LOsG) or sham group

2021 Apr 19

Although the primary endpoint was not achieved, secondary endpoints and exploratory analyses suggest that participants with TNFi-IR PsA, particularly those with elevated CRP, could derive clinically meaningful benefits with guselkumab and golimumab combination therapy, with no new safety concerns, warranting further investigation, the researchers wrote