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First characterised by Raun and colleagues at Novo Nordisk in 1998 (PMID: 9241518), Ipamorelin was designed to deliver potent GH stimulation with a selectivity profile that makes it tractable for isolated study of GH-axis effects without confounding stress-hormone activation

In other words, if swelling and fluid retention has not occurred by month 3, there is a very high likelihood it will not occur

10.1097/01.wnr.0000093297.63079.b3 Neuroreport 23 MagarinosM.PulidoS.AburtoM