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Rothhammer et al., 2016)

Table 2 Summary of the main studies with GLP1-AR

Alternatively, acetylcarnitine, produced in excess in mitochondria by CrAT, is transported into cytosol by CACT and enters the nucleus, where a nuclear CrAT converts the acetylcarnitine to acetyl-CoA 67 , and it becomes a source of acetyl groups for histone acetylation

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Furthermore, intrahepatic and intramyocellular lipid contents are considered to be much better predictors of insulin resistance than visceral adipose tissue volume, which strongly indicates that increased lipid accumulation in liver and skeletal muscle could impair insulin signaling and induce insulin resistance [84,85]