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Megaintestine in claudin-15deficient mice
Its a synthetic analog of natural IGF-1, modified to be significantly more potent and longer-lasting in the bloodstream
Bright GM, Rogers D, Gonzalez-Mendoza LJF: ICE 2008 meeting: 2008
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In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18
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