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Beyond weight loss, Retatrutides triple mechanism produces favorable effects on blood glucose (from GLP-1 and GIP activation), triglycerides (down 28% in trial participants at 48 weeks), blood pressure, and liver fat
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Quick Comparison Table (2026) At-a-Glance: The 5 Key Differences Medication Philosophy: PlushCare still leans heavily toward FDA-approved brand-name medications, but now also supports compounded semaglutide in limited states during shortage periods as a secondary option
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Key safety concerns identified in Phase 2 data include elevated resting heart rate, gastrointestinal side effects, increased hypoglycaemia risk when combined with insulin or sulfonylureas, and class-relevant cautions around pancreatitis and thyroid C-cell tumours
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