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K., Lehner, G

Our first- generation liver targeted PD-L1 small molecule inhibitor, ALG-093702, activated PBMC from an HBV-infected patient ex vivo with similar activity to durvalumab and demonstrated in vivo antitumor efficacy in a human PD-L1 MC38 subcutaneous mice model

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this, in turn, resulted in the upregulated expression of telomere repeat-binding factor 1/2 (TRF1/TRF2) proteins and strict dependence on p53/p21 signaling, followed by irreversible G2/M cell cycle arrest, ultimately leading to apoptosis