Weeks 58: 500 mcg (0.5 mg) once weekly
Selenoproteins can be classified into subfamilies based on their cellular functions such as those implicated in antioxidation (GPX1, GPX2, GPX3, GPX4), redox regulation (TXNRD1, TXNRD2, TXNRD3, MSRB1, SELENOH, SELENOM, SELENOW), thyroid hormone metabolism (DIO1, DIO2, DIO3), selenium transport and storage (SELENOP), selenophosphate synthesis (SEPHS2), calcium metabolism (SELENOK, SELENOT), myogenesis (SELENON), protein folding (SELENOF, SELENOI, SELENOS), and protein AMPylation (SELENOO) 47,48
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Patients with inflammatory bowel disease represent a population requiring particular consideration, as gastrointestinal adverse effects of semaglutide could potentially be confused with disease activity, though there is limited evidence regarding whether the medication directly affects inflammatory bowel disease course
References Albosta, M., & Bakke, J