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Allosteric regulation of ARs transcriptional activity The mechanistic insights reported above are consistent with allosteric regulation of transcription factor action, in which the type of DNA motif to which the factor binds and its protein and ligand interactions influence its conformational plasticity and the availability of tunable multimerization and protein interaction surfaces that control context-dependent and gene-specific transcriptional activity [78, 80]

PMC 3391993

It has been studied extensively ever since

The recommended dose is one 60 mg tablet up to three times a day

There have been rare associations with pancreatitis