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This is often due to the loss of facial fat pads
The side effects are its biggest limitation
The Phase 2 MASH trial (published in NEJM) This 48-week randomized, double-blind, placebo-controlled trial enrolled 293 adults with biopsy-confirmed MASH and fibrosis stages F1 through F3
But heres the catch: while the hype is loud, the science in humans and especially in women is still very thin
Precision matters most at the starting dose because the absolute volumes are small
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