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A small but growing body of evidence has explored this question: Castaeda et al., 2025 ( Lancet Obstetrics, Gynaecology & Womens Health ) Postmenopausal women treated with tirzepatide who were also using menopausal hormone therapy lost approximately 35% more weight than non-users
Urgent need of treatment for AD and PD Despite considerable advances, existing AD and PD treatments primarily address the symptoms rather than the cause
It appears to act as an exercise-responsive endocrine signal that enhances metabolic flexibility without directly suppressing appetite or altering central satiety circuits
Like semaglutide, compounded versions of tirzepatide are available from some pharmacies, though the regulatory situation has its own complexities
Butler J, Shah SJ, Petrie MC et al (2024) Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials
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