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Injecting repeatedly into the same area can, over time, lead to lipohypertrophy (hardened fatty tissue), which may reduce absorption efficiency
Women using oral hormonal contraceptives should use a non-oral method or add a backup method for 4 weeks after starting tirzepatide and after each dose increase
It may however take a few days or weeks (especially if addressing a B12 deficiency)
The risk increases with higher doses of semaglutide and longer duration of exposure
For trips longer than 12 hours, use an insulated medication travel case with ice packs to maintain the 3646F range
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