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In this Review, we discuss similar preclinical studies that present novel concepts in the neural control of food intake and body weight, with reference to endogenous GLP-1, GLP-1R agonists, and bariatric surgeries like Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), which remain the most effective treatments for severe obesity [9]
GLP-1 receptor agonists have been associated with improved kidney function and a reduced risk of kidney failure in individuals with type 2 diabetes and chronic kidney disease
Diabetes 49 , 17511760, doi:10.2337/diabetes.49.11.1751 (2000)
Statistical significance was assessed by by ordinary two-way ANOVA in a , and by unpaired two-tailed t-test in b , c
Its oral small-molecule design improves accessibility and patient compliance compared to injectables
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