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Endometriosis increases the risk of certain gynecologic cancers, particularly ovarian cancer, and any medication that modulates the endometrial environment needs cancer risk assessment

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Along with the direct activation of matrix metalloproteinase-2 (Bescond et al, 1999), vascular damage might also result from an impairment of the tertiary structure of connective tissue protein, because of the reduced degree of cross-linkage between collagen and fibrin monomers (Lubec et al, 1996a