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J Clin Pharm Ther 25:165175 Zhou Y, Ingelman-Sundberg, M, Lauschke, V Worldwide distribution of cytochrome P450 alleles: a meta-analysis of population-scale sequencing projects

Han P, et al

Prolonged chronic stress and dysregulated glucocorticoid levels can disrupt the hippocampal neural circuitry, with characteristic structural alterations, including dendritic atrophy and remodeling, reduced dendritic spine density, and suppressed adult neurogenesis

For the Achilles tendons watershed zone where natural vascularity is poor, this enhanced blood supply can make the difference between successful healing and chronic tendinopathy

This might be a result of the body adapting to the healing process