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The practical research implication is substantial: studies using ipamorelin to investigate GH/IGF-1 axis effects are not confounded by concurrent activation of the hypothalamic-pituitary-adrenal (HPA) axis a major experimental advantage over GHRP-2 and GHRP-6 in any protocol where cortisol or ACTH are outcome variables, or where HPA axis activation would represent an uncontrolled experimental variable

In terms of oxidative stress, levels of malondialdehyde (MDA), 8-iso-prostaglandin F2, and 8-hydroxy-2deoxyguanosine (8-OHdG) were significantly reduced, implying that GLP-1RAs reduce lipid peroxidation and oxidative DNA damage

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