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While it is well known that enhanced insulin sensitivity and low insulin levels are associated with an improved survival, there is evidence showing that attenuation of growth hormone/IGF-1 axis may have beneficial effects in extending lifespan in humans
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The lack of understanding of the signaling cascade between pericyte ferroptosis and endothelial necrosis has made it difficult to select effective vascular-protective targets
presented a magnetically targeted nanocarrier loaded with the PPAR agonist 15d-PGJ2-MNPs, which, when administered intravenously, activated PPAR receptors on macrophages around haematomas, attenuated brain damage, and improved sensory and motor functions in mice after ICH (Wang et al., 2023)
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