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This means the B12 is injected into the fatty tissue just beneath the skin
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The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake
NNMT typically consumes nicotinamide, preventing its conversion into NAD+
Its an invasive procedure that requires breaking the skin, which may be uncomfortable for some individuals
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