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It remains unapproved for human use at time of writing (April 2026)

Abdominal injections tend to provide the fastest absorption rate, which means a sharper peak in medication levels and potentially more intense initial digestive effects

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doi:10.1136/bmjgast-2019-000302 106Tofacitinib (Xeljanz): new measures to minimise risk of venous thromboembolism and of serious and fatal infections

Based on Phase 2 trial data, noticeable weight loss typically becomes apparent between months 3 and 6, with results continuing to accumulate through 48 weeks at higher doses