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For the body, loose skin on the abdomen, upper arms and thighs is common, especially with significant or fast weight loss
For more on that side-effect experience, see why GLP-1 medications can make you tired
Circulating PYY levels tend to normalize in people who have successfully lost weight, whether through lifestyle intervention or bariatric surgery
Other trials investigate how retatrutide compares to drugs such as tirzepatide, which is already showing promise when paired with menopausal hormone therapy to achieve increased weight loss
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