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In the multiple ascending dose study, participants receiving the highest dose level of 48 mg achieved a striking mean body-weight reduction of 9.1% by Day 54, with weight loss trends showing no signs of plateauing

The phase 2 trial showed that the 12mg group lost 24.2% of body weight at 48 weeks versus 8.7% in the 1mg group

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Curr Opin Nephrol Hypertens 11:6772 Barrett CJ, Navakatikyan MA, Malpas SC (2001) Long-term control of renal blood flow: what is the role of the renal nerves

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