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Lifestyle modifications: Patients should be encouraged to: Increase physical activity gradually , starting with low-intensity exercise and building up slowly to avoid excessive breathlessness Practice breathing exercises and relaxation techniques if anxiety is contributing to symptoms Maintain good hydration and manage gastrointestinal side effects, which may indirectly affect breathing comfort Optimise management of pre-existing conditions such as asthma or COPD, including proper inhaler technique and action plans Patient education: Clear communication about what symptoms are expected versus those requiring medical attention is essential

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Regulatory bodies may require a dedicated cardiovascular outcomes trial before or after full approval is granted consistent with the precedent set for other agents in this class though the precise regulatory requirements will be determined by the MHRA and EMA based on the totality of evidence submitted

Risks of angiotensin-converting enzyme inhibition during pregnancy: experimental and clinical evidence, potential mechanisms, and recommendations for use