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Lipoic acid has been found to activate the insulin signaling cascade in cultured cells (3, 42, 43), increase GLUT4 translocation to cell membranes, and increase glucose uptake in cultured adipose and muscle cells (44, 45)
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But it requires a little planning
An 1290 HPLC system (Agilent Technologies, Palo Alto, USA) and a 6460 triple-quadrupole mass spectrometer (Agilent Technologies, Palo Alto, USA) were used
The compound functions as a mammalian oxyntomodulin analogue with a fatty acid side chain that extends its half-life to enable once-weekly dosing
