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Tolerance to Melanotan-2 cycling develops when melanocortin receptors (MC1R for pigmentation, MC4R for appetite suppression) downregulate after 23 weeks of continuous daily dosing
Individual variation exists, but the pattern, rough month 2, improvement month 3, minimal symptoms months 4+, holds for about 85% of patients who complete treatment
Thats because it works by lowering levels of dihydrotestosterone (DHT), which causes hair follicles to shrink
The authors described these molecules as unknown unknowns that may have confounded previous disease models
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