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Incretin hormones are metabolic messengers that tell your pancreas to release insulin and your brain to stop craving food
The substrate-binding domain has a three-layer alpha/beta/alpha structure
10.1038/tp.2016.145 Transl Psychiatry
Insulin resistance results from this because the farnesoid X receptor (FXR) in the ileum is not sufficiently activated
Further elaboration of our understanding of the initiating G-protein coupled receptor (GPCR) circuits engaged locally within the intestine and how they become altered with high-fat diet feeding can offer insight into the dysregulation observed in obesity and diabetes
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