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However, under chronic antigen exposure, these initially activated CD8 + T cells progressively adopt an exhausted phenotype, marked by hierarchical loss of effector functions and memory epigenetic profiles, along with upregulated inhibitory receptors such as PD-1 and CTLA-4, thereby impeding the final steps of the cycle [96, 97]
Strategies for optimizing the response of cancer and normal tissues to radiation
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Kidney health may be tracked at your annual physical if you get blood work done
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